Detailed view for LOAG_03709

Basic information

TDR Targets ID: 949264
Loa Loa (eye worm), Rab6A
Source Database / ID:  KEGG  

pI: 6.2699 | Length (AA): 123 | MW (Da): 14402 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  
GO:0003924   GTPase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 123 2y8e (B) 7 129 78.00 0 1 1.82465 -0.49
11 98 2e9s (B) 13 100 88.00 0 0.91 1.41105 0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127256)

Species Accession Gene Product
Arabidopsis thaliana AT2G44610   Ras-related protein RABH1B
Arabidopsis thaliana AT5G10260   ras-related protein RABH1e
Arabidopsis thaliana AT2G22290   RAB GTPase-like protein H1D
Arabidopsis thaliana AT4G39890   Ras-related protein RABH1c
Babesia bovis BBOV_III004450   Ras family protein
Brugia malayi Bm1_32095   Ras-related protein Rab-6B
Brugia malayi Bm1_32085   rab6
Candida albicans CaO19.8333   similar to S. cerevisiae VPT6 (YLR262C) rab family GTP-binding protein
Candida albicans CaO19.714   similar to S. cerevisiae VPT6 (YLR262C) rab family GTP-binding protein
Caenorhabditis elegans CELE_F59B2.7   Protein RAB-6.1
Caenorhabditis elegans CELE_T25G12.4   Protein RAB-6.2
Cryptosporidium parvum cgd2_1940   RAB6 protein, putative
Dictyostelium discoideum DDB_G0268068   Rab GTPase
Drosophila melanogaster Dmel_CG6601   CG6601 gene product from transcript CG6601-RB
Echinococcus granulosus EgrG_000373050   RAB6A member RAS oncogene family
Entamoeba histolytica EHI_014060   Rab family GTPase
Entamoeba histolytica EHI_157890   Rab family GTPase
Echinococcus multilocularis EmuJ_000373050   RAB6A, member RAS oncogene family
Homo sapiens ENSG00000175582   RAB6A, member RAS oncogene family
Homo sapiens ENSG00000154917   RAB6B, member RAS oncogene family
Leishmania braziliensis LbrM.02.0290   small GTP binding protein rab6-like protein
Leishmania donovani LdBPK_020230.1   small GTP binding protein rab6-like protein
Leishmania infantum LinJ.02.0230   small GTP binding protein rab6-like protein
Leishmania major LmjF.02.0260   small GTP binding protein rab6-like protein
Leishmania mexicana LmxM.02.0260   small GTP binding protein rab6-like protein
Loa Loa (eye worm) LOAG_03709   Rab6A
Loa Loa (eye worm) LOAG_03707   hypothetical protein
Mus musculus ENSMUSG00000030704   RAB6A, member RAS oncogene family
Mus musculus ENSMUSG00000032549   RAB6B, member RAS oncogene family
Neospora caninum NCLIV_054540   RAB5C, member RAS oncogene family, related
Oryza sativa 4343293   Os07g0496000
Plasmodium berghei PBANKA_0904100   ras-related protein Rab-6
Plasmodium falciparum PF3D7_1144900   ras-related protein Rab-6
Plasmodium knowlesi PKNH_0942800   ras-related protein Rab-6, putative
Plasmodium vivax PVX_092850   ras-related protein Rab-6, putative
Plasmodium yoelii PY00721   Rab6
Saccharomyces cerevisiae YLR262C   Rab family GTPase YPT6
Schistosoma japonicum Sjp_0019960   ko:K07976 Rab family, other, putative
Schistosoma mansoni Smp_163580   rab6
Schmidtea mediterranea mk4.005399.05   Ras-related protein Rab6
Schmidtea mediterranea mk4.008220.00   Ras-related protein Rab6
Schmidtea mediterranea mk4.005670.02   Ras-related protein Rab6
Schmidtea mediterranea mk4.005399.03   Ras-related protein Rab6
Trypanosoma brucei gambiense Tbg.972.2.700   small GTP-binding protein RAB6, putative
Trypanosoma brucei Tb927.2.2130   small GTP-binding protein RAB6, putative
Trypanosoma congolense TcIL3000_0_54860   small GTP-binding protein RAB6, putative
Trypanosoma cruzi TcCLB.505037.50   small GTP-binding protein RAB6, putative
Trypanosoma cruzi TcCLB.510077.40   small GTP-binding protein RAB6, putative
Toxoplasma gondii TGME49_310460   Rab6
Theileria parva TP02_0799   GTP-binding protein rab6, putative
Trichomonas vaginalis TVAG_153440   RAB, putative
Trichomonas vaginalis TVAG_377960   Rab8, putative
Trichomonas vaginalis TVAG_297320   small GTPase rabi, putative
Trichomonas vaginalis TVAG_036230   RAB, putative
Trichomonas vaginalis TVAG_440690   small GTPase rabh, putative

Essentiality

LOAG_03709 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.2130 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.2130 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.2.2130 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.2130 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0904100 Plasmodium berghei Essential plasmo
TGME49_310460 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_03709 (Loa Loa (eye worm)), Rab6A
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